Associations of plasma high-sensitivity C-reactive protein concentrations with all-cause and cause-specific mortality among middle-aged and elderly individuals

Table 2 HRs (95% CI) for all-cause, cardiovascular and cancer mortality stratified by baseline high-sensitivity C-reactive protein concentration quartiles

HsCRP quartiles	All-cause mortality		Cardiovascular mortality		Cancer mortality
HsCRP quartiles	Model 1^a	Model 2^b	Model 1	Model 2	Model 1	Model 2
No. of participants	14,220		14,220		14,220
Person-years at risk	80,572		80,572		80,572
No. of events	1730		608		351
Q1	1.00 (reference)	1.00 (reference)	1.00 (reference)	1.00 (reference)	1.00 (reference)	1.00 (reference)
Q2	1.02 (0.88–1.17)	1.06 (0.92–1.22)	1.07 (0.84–1.36)	1.09 (0.82–1.33)	1.05 (0.76–1.44)	1.07 (0.78–1.48)
Q3	1.17 (1.02–1.35)*	1.18 (1.03–1.36)*	1.28 (1.01–1.62)*	1.26 (1.00–1.57)	1.23 (0.90–1.69)	1.23 (0.90–1.69)
Q4	1.59 (1.40–1.82)***	1.50 (1.31–1.72)***	1.62 (1.29–2.04)***	1.44 (1.13–1.82)**	1.71 (1.27–2.29)***	1.67 (1.23–2.26)**
P for trend	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001

^aModel 1: adjusted for age and sex
^bModel 2: adjusted for age, sex, race, educational level, current smoking status, alcohol consumption, regular exercise, body mass index (BMI), household income, total cholesterol (TC) concentration, high density lipoprotein-cholesterol (HDL-C) concentration, hemoglobin A1c (HbA1c) at the endCES-D 8 score, hypertension, heart disease, stroke, diabetes, pulmonary disorder, psychiatric problems, and limitations in activities of daily living (ADLs)
* P < 0.05; ** P < 0.01; *** P < 0.001

ISSN: 1742-4933